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Article

Direct evidence for thymic function in adult humans.

The Journal of experimental medicine - 16 Aug 1999

Poulin J F, Viswanathan M N, Harris J M, Komanduri K V, Wieder E, Ringuette N, Jenkins M, McCune J M, Sékaly R P

Abstract excerpt

The understanding of human thymic function and evaluation of its contribution to T cell homeostasis are matters of great importance. Here we report the development of a novel assay to quantitate the frequency and diversity of recent thymic emigrants (RTEs) in the peripheral blood of humans. Such cells were defined by the presence of T cell receptor (TCR) rearrangement deletion circles (DCs), episomal byproducts...

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Source

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Identifiers

PMID: 10449519
DOI: 10.1084/jem.190.4.479
PMCID: PMC2195604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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