Article
Accurate Quantification of T Cells by Measuring Loss of Germline T-Cell Receptor Loci with Generic Single Duplex Droplet Digital PCR Assays.
The Journal of molecular diagnostics : JMD - 1 Mar 2017
Zoutman Willem H, Nell Rogier J, Versluis Mieke, van Steenderen Debby, Lalai Rajshri N, Out-Luiting Jacoba J, de Lange Mark J, Vermeer Maarten H, Langerak Anton W, van der Velden Pieter A
Abstract excerpt
Quantifying T cells accurately in a variety of tissues of benign, inflammatory, or malignant origin can be of great importance in a variety of clinical applications. Flow cytometry and immunohistochemistry are considered to be gold-standard methods for T-cell quantification. However, these methods require fresh, frozen, or fixated cells and tissue of a certain quality. In addition, conventional and droplet...
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