Article
TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity.
Clinical and experimental immunology - 1 Oct 2020
Dasouki M, Jabr A, AlDakheel G, Elbadaoui F, Alazami A M, Al-Saud B, Arnaout R, Aldhekri H, Alotaibi I, Al-Mousa H, Hawwari A
Abstract excerpt
Primary immune deficiency (PID) disorders are clinically and molecularly heterogeneous diseases. T cell receptor excision circles (TRECs) and κ (kappa)-deleting excision circles (KRECs) are markers of T and B cell development, respectively. They are useful tools to assess T and B cell function and immune reconstitution and have been used for newborn screening for severe combined immunodeficiency disease (SCID)...
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