Article
BRAF Dimerization: An Underlying Resistance Mechanism in Low-Grade Pediatric Gliomas.
Cancer discovery - 1 Sept 2018
Romano Gabriele, Kwong Lawrence N
Abstract excerpt
BRAF fusions and mutations are the most frequent genetic alterations in pediatric low-grade gliomas. The work from Wang and colleagues identifies an acquired secondary BRAF mutation that confers resistance to pharmacologic BRAF inhibition in a BRAFV600E glioma. The authors demonstrate that the mutation results in increased BRAF homodimerization, which in turn is targetable with second-generation BRAF inhibitors....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.