Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.

doi:10.1093/neuonc/noac096

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Article

Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.

Neuro-oncology - 2 Nov 2022

Rosenberg Tom, Yeo Kee Kiat, Mauguen Audrey, Alexandrescu Sanda, Prabhu Sanjay P, Tsai Jessica W, Malinowski Seth, Joshirao Mrinal, Parikh Karishma, Farouk Sait Sameer, Rosenblum Marc K, Benhamida Jamal K, Michaiel George, Tran Hung N, Dahiya Sonika, Kachurak Kara, Friedman Gregory K, Krystal Julie I, Huang Michael A, Margol Ashley S, Wright Karen D, Aguilera Dolly, MacDonald Tobey J, Chi Susan N, Karajannis Matthias A

Abstract excerpt

BACKGROUND: The prognosis for patients with pediatric high-grade glioma (pHGG) is poor despite aggressive multimodal therapy. Objective responses to targeted therapy with BRAF inhibitors have been reported in some patients with recurrent BRAF-mutant pHGG but are rarely sustained. METHODS: We performed a retrospective, multi-institutional review of patients with BRAF-mutant pHGG treated with off-label BRAF +/- MEK...

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Identifiers

PMID: 35397478
DOI: 10.1093/neuonc/noac096
PMCID: PMC9629451

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