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Article

Substrate-assisted enzymatic formation of lysinoalanine in duramycin.

Nature chemical biology - 1 Oct 2018

An Linna, Cogan Dillon P, Navo Claudio D, Jiménez-Osés Gonzalo, Nair Satish K, van der Donk Wilfred A

Abstract excerpt

Duramycin is a heavily post-translationally modified peptide that binds phosphatidylethanolamine. It has been investigated as an antibiotic, an inhibitor of viral entry, a therapeutic for cystic fibrosis, and a tumor and vasculature imaging agent. Duramycin contains a β-hydroxylated Asp (Hya) and four macrocycles, including an essential lysinoalanine (Lal) cross-link. The mechanism of Lal formation is not known....

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Identifiers

PMID: 30177849
DOI: 10.1038/s41589-018-0122-4
PMCID: PMC6372306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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