Article
Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin.
Biophysical journal - 1 Sept 2007
Iwamoto Kunihiko, Hayakawa Tomohiro, Murate Motohide, Makino Asami, Ito Kazuki, Fujisawa Tetsuro, Kobayashi Toshihide
Abstract excerpt
Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and...
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