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Article

Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours.

Veterinary and comparative oncology - 1 Dec 2018

Canadas Ana, Santos Marta, Pinto Ricardo, Medeiros Rui, Dias-Pereira Patrícia

Abstract excerpt

The enzyme catechol-o-methyltransferase (COMT) is responsible for inactivation of catechol estrogens, which are well-recognized carcinogenic metabolites. Two single-nucleotide polymorphisms (SNPs) in canine COMT gene were previously associated with the age of onset of mammary tumours and with the clinical progression of the disease. However, no information is available regarding the impact of other known SNPs in...

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Identifiers

PMID: 30168237
DOI: 10.1111/vco.12438

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COMT

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