Article
Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome.
Glia - 1 Nov 2018
Cheli Veronica T, Santiago González Diara A, Zamora Norma N, Lama Tenzing N, Spreuer Vilma, Rasmusson Randall L, Bett Glenna C, Panagiotakos Georgia, Paez Pablo M
Abstract excerpt
To study the role of L-type voltage-gated Ca++ channels in oligodendrocyte development, we used a mouse model of Timothy syndrome (TS) in which a gain-of-function mutation in the α1 subunit of the L-type Ca++ channel Cav1.2 gives rise to an autism spectrum disorder (ASD). Oligodendrocyte progenitor cells (OPCs) isolated from the cortex of TS mice showed greater L-type Ca++ influx and displayed characteristics...
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