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Article

In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

Clinical pharmacology and therapeutics - 1 Nov 2004

Gurley Bill J, Gardner Stephanie F, Hubbard Martha A, Williams D Keith, Gentry W Brooks, Carrier Julie, Khan Ikhlas A, Edwards David J, Shah Amit

Abstract excerpt

OBJECTIVES: Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of Citrus aurantium , Echinacea purpurea , milk thistle (Silybum marianu...

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Identifiers

PMID: 15536458
DOI: 10.1016/j.clpt.2004.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15536458-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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