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Pan-cancer analysis of neoepitopes

20 Aug 2018

Abstract excerpt

Somatic variations are frequent and important drivers in cancers. Amino acid substitutions can yield neoantigens that are detected by the immune system. Neoantigens can lead to immune response and tumor rejection. Although neoantigen load and occurrence have been widely studied, a detailed pan-cancer analysis of the occurrence and characterization of neoepitopes is missing. We investigated the proteome-wide amino...

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PMID: 30143704
DOI: 10.1038/s41598-018-30724-y

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