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Article

A meta-analysis of experimentally validated neo-epitopes: patterns, biases, and opportunities.

Cancer immunology, immunotherapy : CII - 6 Nov 2025

Sette Alessandro, Carri Ibel, Marrama Daniel, Frentzen Angela, Mahita Jarjapu, Blazeska Nina, Vita Randi, Nielsen Morten, Wan Yat-Tsai Richie, Carter Hannah, Schoenberger Stephen, Peters Bjoern, Koşaloğlu-Yalçın Zeynep

Abstract excerpt

Cancer cells harbor somatic mutations that generate novel amino acid sequences that are absent in the self-proteome. These mutation-derived cancer-specific peptides are defined as "neo-peptides". Neo-peptides eliciting immune responses, i.e. immunogenic neo-peptides, are defined as "neo-epitopes". Given their relevance to cancer immunotherapy, we conducted a meta-analysis to examine how experimental evidence...

Read the complete abstract on PubMed

Topics

Humans
Neoplasms
Mutation
Epitopes
Immunotherapy
Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antigens, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 41196374
DOI: 10.1007/s00262-025-04209-7
PMCID: PMC12592574

Genes

KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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