Article
Role of in silico structural modeling in predicting immunogenic neoepitopes for cancer vaccine development.
JCI insight - 3 Sept 2020
Zaidi Neeha, Soban Mariya, Chen Fangluo, Kinkead Heather, Mathew Jocelyn, Yarchoan Mark, Armstrong Todd D, Haider Shozeb, Jaffee Elizabeth M
Abstract excerpt
In prior studies, we delineated the landscape of neoantigens arising from nonsynonymous point mutations in a murine pancreatic cancer model, Panc02. We developed a peptide vaccine by targeting neoantigens predicted using a pipeline that incorporates the MHC binding algorithm NetMHC. The vaccine, when combined with immune checkpoint modulators, elicited a robust neoepitope-specific antitumor immune response and...
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