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Article

cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg.

PLoS genetics - 1 Aug 2018

Newcomb Susan, Voutev Roumen, Jory Aurelie, Delker Rebecca K, Slattery Matthew, Mann Richard S

Abstract excerpt

We characterized the establishment of an Epidermal Growth Factor Receptor (EGFR) organizing center (EOC) during leg development in Drosophila melanogaster. Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each through single enhancers, vnE and rhoE, that integrate inputs from Wg, Dpp, Dll and Sp1. Deletion of vnE and rhoE...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30142157
DOI: 10.1371/journal.pgen.1007568
PMCID: PMC6147608

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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