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Article

Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method.

Journal of proteome research - 5 Oct 2018

Shi Jian, Wang Xinwen, Zhu Huaijun, Jiang Hui, Wang Danxin, Nesvizhskii Alexey, Zhu Hao-Jie

Abstract excerpt

Measuring allele-specific expression (ASE) is a powerful approach for identifying cis-regulatory genetic variants. Here, we developed a novel targeted proteomics method for the quantification of allele-specific protein expression (ASPE) based on scheduled parallel reaction monitoring (PRM) with a heavy stable isotope-labeled quantitative concatamer (QconCAT) internal protein standard. This strategy was applied to...

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Identifiers

PMID: 30141943
DOI: 10.1021/acs.jproteome.8b00620
PMCID: PMC6309561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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