Article
Intergenic Splicing between Four Adjacent UGT Genes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.
Molecular pharmacology - 1 Sept 2018
Hu Dong Gui, Hulin Julie-Ann, Wijayakumara Dhilushi D, McKinnon Ross A, Mackenzie Peter I, Meech Robyn
Abstract excerpt
Recent studies have investigated alternative splicing profiles of UDP-glucuronosyltransferase (UGT) genes and identified over 130 different alternatively spliced UGT transcripts. Although UGT genes are highly clustered, the formation of chimeric transcripts by intergenic splicing between two or more UGT genes has not yet been reported. This study identified 12 chimeric transcripts (chimeras A-L) containing exons...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.