Cleaning up alpha-1 antitrypsin deficiency related liver disease.

doi:10.1097/MOG.0000000000000919

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Article

Cleaning up alpha-1 antitrypsin deficiency related liver disease.

Current opinion in gastroenterology - 1 May 2023

Rademacher Laura, Fromme Malin, Strnad Pavel

Abstract excerpt

PURPOSE OF REVIEW: Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic disorders arising due to mutations in alpha-1 antitrypsin (AAT) gene affecting primarily the lung and the liver. This review summarizes the pathophysiology and clinical manifestation of different AATD genotypes and discusses the recent therapeutic developments. The focus is on the severe, rare homozygous Pi∗ZZ and the...

Topics

Humans
alpha 1-Antitrypsin Deficiency
Liver Cirrhosis
Genotype
Liver Transplantation

Source

Open in PubMed

Identifiers

PMID: 37144533
DOI: 10.1097/MOG.0000000000000919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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