Article
Liver disease in alpha 1-antitrypsin deficiency: a review.
The American journal of gastroenterology - 1 Aug 2008
Fairbanks Kyrsten D, Tavill Anthony S
Abstract excerpt
Alpha 1-antitrypsin deficiency is an inherited metabolic disorder that predisposes the affected individual to chronic pulmonary disease, in addition to chronic liver disease, cirrhosis, and hepatocellular carcinoma. Just over one-third of genetically susceptible adult patients with the most severe phenotype, PiZZ, develop clinically significant liver injury. The clinical presentation of liver disease is variable,...
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