Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target

24 Jul 2018

Abstract excerpt

Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relationships are changed in late-onset Alzheimer’s disease. We have now examined how proteins are incorporated into networks in two separate series and evaluated our outputs in two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Endoplasmic Reticulum Stress and Disease
Share to Heat shock proteins research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30137212
DOI: 10.1093/brain/awy215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease targetPMID 30137212Read ↗

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read ↗

Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse modelsSemantic proximity Read ↗

Decoding Pathogenic Mutational Landscapes in Alzheimer's Disease Through Integrated Transcriptomics.Semantic proximity Read ↗

An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease.Semantic proximity Read ↗

Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer’s diseaseSemantic proximity Read ↗

Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity Read ↗

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read ↗

Identification of network-based differential gene expression signatures and their transcriptional factors to develop progressive blood biomarkers for Alzheimer’s diseaseSemantic proximity Read ↗

Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimer’s DiseaseSemantic proximity Read ↗

Cross-Tissue WGCNA Reveals Conserved Brain-Blood Transcriptomic Signatures and Potential Biomarkers for Asymptomatic Alzheimer's Disease DiagnosisSemantic proximity Read ↗

Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adultsSemantic proximity Read ↗

Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.