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Dictyostelium discoideum: An Alternative Nonanimal Model for Developmental Toxicity Testing.

Toxicological sciences : an official journal of the Society of Toxicology - 28 Sept 2021

Baines Robert P, Wolton Kathryn, Thompson Christopher R L

Abstract excerpt

A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted in vivo in mammalian model systems. New legislation aimed at reducing animal use and the prohibitive costs associated with DART testing, together with a need to understand the genetic pathways underlying developmental toxicity means there is a growing demand for...

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PMID: 34387693
DOI: 10.1093/toxsci/kfab097
PMCID: PMC8538044

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