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Why Tumor Genetic Heterogeneity May Require Rethinking Cancer Genesis and Treatment.

Trends in cancer - 1 May 2021

Gottlieb Bruce, Trifiro Mark, Batist Gerald

Abstract excerpt

Tumor genetic heterogeneity, in which individual tumors contain both multiple variant cancer-associated and normal genes, has been widely reported, although its significance has yet to be fully understood. We propose a genetic heterogeneity-based selection-centric hypothesis in which genetic heterogeneity, caused by the temporary reduction of DNA repair efficiency, occurs very early in human development,...

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PMID: 33243702
DOI: 10.1016/j.trecan.2020.10.013

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