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Article

Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity.

Cell reports - 21 Aug 2018

Campbell Katie M, Lin Tianxiang, Zolkind Paul, Barnell Erica K, Skidmore Zachary L, Winkler Ashley E, Law Jonathan H, Mardis Elaine R, Wartman Lukas D, Adkins Douglas R, Chernock Rebecca D, Griffith Malachi, Uppaluri Ravindra, Griffith Obi L

Abstract excerpt

Herein, we report an oral cavity squamous cell carcinoma (OCSCC) patient-derived xenograft (PDX) platform, with genomic annotation useful for co-clinical trial and mechanistic studies. Genomic analysis included whole-exome sequencing (WES) and transcriptome sequencing (RNA-seq) on 16 tumors and matched PDXs and additional whole-genome sequencing (WGS) on 9 of these pairs as a representative subset of a larger...

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Identifiers

PMID: 30134176
DOI: 10.1016/j.celrep.2018.07.058
PMCID: PMC6417872

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