Article

Instability in 18S and 5.8S rDNA copy numbers and 18S:5.8S ratios in longitudinally-collected human DNA samples detected by monochrome multiplex qPCR

2018-07-04

Abstract excerpt

Ribosomal DNA encodes the structural RNAs of the ribosomes. Ribosomal DNA instability is a major contributor to aging in yeast, but its role in human aging and longevity is largely unknown. Human 45S rDNA encodes the 18S, 5.8S, and 28S ribosomal RNAs; ranges in copy number from 60 to > 800 per cell, distributed as tandem repeats along the short arms of the five acrocentric chromosomes (p13, p14, p15, p21, and p22)...

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Literature Corpus work: 10e7c9e9-add8-5511-b150-88031d0ff3fc
DOI: 10.1101/361840

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