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Article

Mutations causing low level antibiotic resistance ensure bacterial survival in antibiotic-treated hosts.

Scientific reports - 21 Aug 2018

Frimodt-Møller Jakob, Rossi Elio, Haagensen Janus Anders Juul, Falcone Marilena, Molin Søren, Johansen Helle Krogh

Abstract excerpt

In 474 genome sequenced Pseudomonas aeruginosa isolates from 34 cystic fibrosis (CF) patients, 40% of these harbor mutations in the mexZ gene encoding a negative regulator of the MexXY-OprM efflux pump associated with aminoglycoside and fluoroquinolone resistance. Surprisingly, resistance to aminoglycosides and fluoroquinolones of mexZ mutants was far below the breakpoint of clinical resistance. However, the...

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Identifiers

PMID: 30131514
DOI: 10.1038/s41598-018-30972-y
PMCID: PMC6104031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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