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Article

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance.

Nature communications - 22 Mar 2024

Laborda Pablo, Lolle Signe, Hernando-Amado Sara, Alcalde-Rico Manuel, Aanæs Kasper, Martínez José Luis, Molin Søren, Johansen Helle Krogh

Abstract excerpt

Mutations in mexZ, encoding a negative regulator of the expression of the mexXY efflux pump genes, are frequently acquired by Pseudomonas aeruginosa at early stages of lung infection. Although traditionally related to resistance to the first-line drug tobramycin, mexZ mutations are associated with low-level aminoglycoside resistance when determined in the laboratory, suggesting that their selection during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38519499
DOI: 10.1038/s41467-024-46938-w
PMCID: PMC10959964

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Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance.PMID 38519499Read ↗

Efflux pump mutations in <i>Pseudomonas aeruginosa</i> cause low-level clinical resistance and high-level tolerance to antibiotics in patientsSemantic proximity Read ↗

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Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly CorrelatedSemantic proximity Read ↗

Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Mutations causing low level antibiotic resistance ensure bacterial survival in antibiotic-treated hosts.Semantic proximity Read ↗

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Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ.Semantic proximity Read ↗

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

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