Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.

doi:10.1038/s41436-018-0009-5

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Article

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2019

Yurgelun Matthew B, Chittenden Anu B, Morales-Oyarvide Vicente, Rubinson Douglas A, Dunne Richard F, Kozak Margaret M, Qian Zhi Rong, Welch Marisa W, Brais Lauren K, Da Silva Annacarolina, Bui Justin L, Yuan Chen, Li Tingting, Li Wanwan, Masuda Atsuhiro, Gu Mancang, Bullock Andrea J, Chang Daniel T, Clancy Thomas E, Linehan David C, Findeis-Hosey Jennifer J, Doyle Leona A, Thorner Aaron R, Ducar Matthew D, Wollison Bruce M, Khalaf Natalia, Perez Kimberly, Syngal Sapna, Aguirre Andrew J, Hahn William C, Meyerson Matthew L, Fuchs Charles S, Ogino Shuji, Hornick Jason L, Hezel Aram F, Koong Albert C, Nowak Jonathan A, Wolpin Brian M

Abstract excerpt

PURPOSE: Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. We sought to determine the prevalence and significance of germline cancer susceptibility gene variants in PDAC with paired somatic and survival analyses. METHODS:...

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Identifiers

PMID: 29961768
DOI: 10.1038/s41436-018-0009-5
PMCID: PMC6666401

Genes

BRCA1
APC
ATM
BRCA2
BRIP1
CHEK2
NBN
PALB2
RAD50

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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