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Management of BRCA Mutation Carriers With Pancreatic Adenocarcinoma.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Apr 2021

Golan Talia, Hammel Pascal

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a 5-year survival rate of ≤7% across all stages. Most patients are diagnosed with advanced disease and median overall survival is limited. The limited success of conventional therapies for PDAC is at least partially attributable to its genetic heterogeneity. Extensive genomic efforts have been made to subtype PDAC. The DNA damage repair (DDR)...

Topics

Adenocarcinoma
Genes, BRCA1
Genes, BRCA2
Genomics
Heterozygote
Humans
Mutation
Pancreatic Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33845459
DOI: 10.6004/jnccn.2021.7031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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