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Article

Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression.

Immunobiology - 1 Dec 2018

González Andrea, Härtel Steffen, Mansilla Jorge, Sánchez-Valdéz Fernando, Ferreira Arturo

Abstract excerpt

Trypanosoma cruzi calreticulin (TcCalr, formerly known as TcCRT), upon binding to Complement (C) C1 and ficolins, inhibits the classical and lectin pathways and promotes infectivity. This virulence correlates with the expression of TcCalr. The TcCalr C inhibitory capacity was shown in a previous work using a clonal epimastigote cell line from the TCC T. cruzi strain, lacking one TcCalr allele (TcCalr+/-) or over...

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Identifiers

PMID: 30131175
DOI: 10.1016/j.imbio.2018.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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