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Article

Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells.

Journal of cell science - 1 Mar 2005

Santos Camila C, Sant'anna Celso, Terres Amanda, Cunha-e-Silva Narcisa L, Scharfstein Julio, de A Lima Ana Paula C

Abstract excerpt

Chagasin is a Trypanosoma cruzi protein that was recently characterized as a tight-binding inhibitor of papain-like cysteine proteases (CPs). Considering that parasite virulence and morphogenesis depend on the endogenous activity of lysosomal CPs of the cruzipain family, we sought to determine wh...

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Identifiers

PMID: 15713748
DOI: 10.1242/jcs.01677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15713748-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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