The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence

Abstract excerpt

Because of its capacity to increase a physiologic inflammatory response, to stimulate phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the complement system is a crucial component of both the innate and adaptive immune responses. However, many infectious agents resist the activation of this system by expressing or secreting proteins with a role as Complement regulatory, mainly...

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