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Article

MicroRNA-221 silencing attenuates the degenerated phenotype of intervertebral disc cells.

Aging - 20 Aug 2018

Penolazzi Letizia, Lambertini Elisabetta, Bergamin Leticia Scussel, Roncada Tosca, De Bonis Pasquale, Cavallo Michele, Piva Roberta

Abstract excerpt

The aim of this study was to investigate the role of an antichondrogenic factor, MIR221 (miR-221), in intervertebral disc degeneration (IDD), and provide basic information for the development of a therapeutic strategy for the disc repair based on specific nucleic acid based drugs, such as miR-221 silencing. We established a relatively quick protocol to minimize artifacts from extended in vitro culture, without...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30130742
DOI: 10.18632/aging.101525
PMCID: PMC6128426

Genes

FOXO3
ACAN
IVD
SOX9
TRPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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