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Article

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

20 Aug 2018

Abstract excerpt

ABSTRACT Male fertility is dependent on spermatogonial stem cells (SSCs) that self-renew and produce differentiating germ cells. Growth factors produced within the testis are essential for SSC maintenance but intrinsic factors that dictate the SSC response to these stimuli are poorly characterised. Here, we have studied the role of GILZ, a TSC22D family protein and spermatogenesis regulator, in spermatogonial...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30126904
DOI: 10.1242/dev.165324

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