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Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease

16 Aug 2024

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder with early autophagy deficits. Our study probed the role of lysosomal-related genes (LRGs) in AD. Using the Gene Expression Omnibus (GEO) database, we analyzed differentially expressed genes (DEGs) in AD. AD-related genes and lysosomal-related genes (LRGs) were extracted from public databases. Leveraging the UpSetR package, we identified differentially...

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PMID: 39150655
DOI: 10.1007/s11011-024-01409-5

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