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Article

miR-22 suppresses DNA ligase III addiction in multiple myeloma

17 Aug 2018

Abstract excerpt

Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability. Here we provide evidence that hyper-activation of DNA ligase III (LIG3) is crucial for genomic instability and survival of MM cells. LIG3 mRNA expression in MM patients correlates with shorter survival and even increases with more advanced stage of disease. Knockdown of LIG3 impairs MM cells viability in vitro and in...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Multiple Myeloma Research and Treatments

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PMID: 30120376
DOI: 10.1038/s41375-018-0238-2

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