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Article

The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder.

European archives of psychiatry and clinical neuroscience - 1 Jun 2016

Martín-Blanco Ana, Ferrer Marc, Soler Joaquim, Arranz Maria Jesús, Vega Daniel, Calvo Natalia, Elices Matilde, Sanchez-Mora Cristina, García-Martinez Iris, Salazar Juliana, Carmona Cristina, Bauzà Joana, Prat Mónica, Pérez Víctor, Pascual Juan C

Abstract excerpt

Current knowledge suggests that borderline personality disorder (BPD) results from the interaction between genetic and environmental factors. Research has mainly focused on monoaminergic genetic variants and their modulation by traumatic events, especially those occurring during childhood. However, to the best of our knowledge, there are no studies on the genetics of hypothalamus-pituitary-adrenal (HPA) axis,...

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Source

Identifiers

PMID: 26182893
DOI: 10.1007/s00406-015-0612-2

Genes

FKBP5
CRHR1
CRHR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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