Article
High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.
Nature genetics - 1 Sept 2018
Palamara Pier Francesco, Terhorst Jonathan, Song Yun S, Price Alkes L
Abstract excerpt
Interest in reconstructing demographic histories has motivated the development of methods to estimate locus-specific pairwise coalescence times from whole-genome sequencing data. Here we introduce a powerful new method, ASMC, that can estimate coalescence times using only SNP array data, and is orders of magnitude faster than previous approaches. We applied ASMC to detect recent positive selection in 113,851...
Topics
- Disease
- Genome-Wide Association Study
- High-Throughput Screening Assays
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Molecular Sequence Annotation
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci