Article

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

2023-03-03

Abstract excerpt

The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode for active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded. Here, we report the identification of a mitochondrial-encoded host defense peptide (HDP) that presumably derives from the primordial proto-mitochondrial bacteria. We demonstrate that MOTS-c (m...

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Identifiers and source

Literature Corpus work: 7e26db0d-81d8-543e-a6c6-5ca089495ce3
DOI: 10.1101/2023.03.02.530691

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