Article
Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes.
PLoS biology - 1 Aug 2018
Fedry Juliette, Forcina Jennifer, Legrand Pierre, Péhau-Arnaudet Gérard, Haouz Ahmed, Johnson Mark, Rey Felix A, Krey Thomas
Abstract excerpt
HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the functional conformation of the HAP2 fusion loops has remained unknown, as the reported X-ray structure of Chlamydomonas reinhardtii HAP2 lacked...
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