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Adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in African trypanosomatids

19 Jan 2013

Abstract excerpt

The kinetoplastids are an important group of protozoa from the Excavata supergroup, and cause numerous diseases with wide environmental, economic and ecological impact. Trypanosoma brucei, the causative agent of human African trypanosomiasis, expresses a dense variant surface glycoprotein (VSG) coat, facilitating immune evasion via rapid switching and antigenic variation. Coupled to VSG switching is efficient...

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PMID: 23337175
DOI: 10.1016/j.ympev.2013.01.002

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