Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

1 Dec 2017

Abstract excerpt

Inhibiting transmission of Plasmodium is a central strategy in malarial eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. The lack of a structure or known molecular function of current anti-malarial vaccine targets has previously been a hindrance in the development of transmission-blocking vaccines. Structure/function studies have indicated that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29212032
DOI: 10.1016/j.celrep.2017.11.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparumPMID 29212032Read ↗

Evaluation of Plasmodium vivax HAP2 as a transmission-blocking vaccine candidateSemantic proximity Read ↗

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen <i>Plasmodium falciparum</i> HAP2Semantic proximity Read ↗

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitroSemantic proximity Read ↗

<i>Plasmodium</i> P25 and P28 Surface Proteins: Potential Transmission-Blocking VaccinesSemantic proximity Read ↗

Disruption of the AgMOBP1–PfSyn5 interface abolishes malaria transmissionSemantic proximity Read ↗

The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitroSemantic proximity Read ↗

Pfs48/45 nanobodies block <i>Plasmodium falciparum</i> transmissionSemantic proximity Read ↗

Evaluation of transmission-blocking potential of Pv22 using clinical Plasmodium vivax infections and transgenic Plasmodium bergheiSemantic proximity Read ↗

Structure-Function Studies Link Class II Viral Fusogens with the Ancestral Gamete Fusion Protein HAP2.Semantic proximity Read ↗

Malaria adhesins: structure and functionSemantic proximity Read ↗

Transmission-reducing and -enhancing monoclonal antibodies against Plasmodium vivax gamete surface protein Pvs48/45Semantic proximity Read ↗

Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.