Article
A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia.
Bioinformatics (Oxford, England) - 15 Feb 2019
Li Miaoxin, Jiang Lin, Mak Timothy Shin Heng, Kwan Johnny Sheung Him, Xue Chao, Chen Peikai, Leung Henry Chi-Ming, Cui Liqian, Li Tao, Sham Pak Chung
Abstract excerpt
MOTIVATION: It remains challenging to unravel new susceptibility genes of complex diseases and the mechanisms in genome-wide association studies. There are at least two difficulties, isolation of the genuine susceptibility genes from many indirectly associated genes and functional validation of these genes. RESULTS: We first proposed a novel conditional gene-based association test which can use only summary...
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