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Article

An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C.

The pharmacogenomics journal - 1 Jun 2019

Soko Nyarai Desiree, Chimusa Emile, Masimirembwa Collen, Dandara Collet

Abstract excerpt

Studies in Caucasian and Asian populations consistently associated interindividual and interethnic variability in rosuvastatin pharmacokinetics to the polymorphisms SLCO1B1 c.521T>C (rs4149056 p. Val174Ala) and ABCG2 c.421C>A (rs2231142, p. Gln141Lys). To investigate the pharmacogenetics of rosuvastatin in African populations, we first screened 785 individuals from nine ethnic African populations for the SLCO1B1...

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Identifiers

PMID: 30100615
DOI: 10.1038/s41397-018-0035-3

Genes

ABCG2
ABCB11
ABCC2
AHR
FOXA3
RXRA

Variants

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