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Article

Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line.

Biochemical and biophysical research communications - 18 Sept 2018

Shim Myoung Sup, Kim Keun-Young, Noh Mark, Ko Ji Yoon, Ahn Sangphil, An Michelle A, Iwata Takeshi, Perkins Guy A, Weinreb Robert N, Ju Won-Kyu

Abstract excerpt

Optineurin (OPTN) mutations are linked to glaucoma pathology and E50K mutation shows massive cell death in photoreceptor cells and retinal ganglion cells. However, little is known about E50K-mediated mitochondrial dysfunction in photoreceptor cell degeneration. We here show that overexpression of E50K expression triggered BDNF deficiency, leading to Bax activation in RGC-5 cells. BDNF deficiency induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30100066
DOI: 10.1016/j.bbrc.2018.08.025
PMCID: PMC6133749

Genes

BDNF
OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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