Article
Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury.
Archives of biochemistry and biophysics - 1 Oct 2018
Sánchez Campos Sofía, Alza Natalia P, Salvador Gabriela A
Abstract excerpt
Pathological α-synuclein (α-syn) overexpression and iron (Fe)-induced oxidative stress (OS) are involved in the death of dopaminergic neurons in Parkinson's disease (PD). We have previously characterized the role of triacylglycerol (TAG) formation in the neuronal response to Fe-induced OS. In this work we characterize the role of the α-syn variant A53T during Fe-induced injury and investigate whether lipid...
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