Article
Histone H3K36M mutation and trimethylation patterns in chondroblastoma.
Histopathology - 1 Jan 2019
Lu Chuanyong, Ramirez Daniel, Hwang Sinchun, Jungbluth Achim, Frosina Denise, Ntiamoah Peter, Healey John, Zhu Guo, Chen Wen, Klein Michael, Hameed Meera
Abstract excerpt
AIMS: Histones are essential components of chromatin, and mutations in histones lead to alterations in methylation and acetylation, which play an important role in tumorigenesis. Most of the chondroblastomas harbour the H3K36M mutation. With the availability of a mutation-specific antibody, we sought to assess the sensitivity of this antibody and the alterations of histone methylation in a series of...
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