Article
Genotypic groups as risk factors for cardiac magnetic resonance abnormalities and complications in thalassemia major: a large, multicentre study.
Blood transfusion = Trasfusione del sangue - 1 Mar 2021
Pistoia Laura, Meloni Antonella, Ricchi Paolo, Filosa Aldo, Lisi Roberto, Maggio Aurelio, Rosso Rosamaria, Messina Giuseppe, Iacono Nicola Dello, Cuccia Liana, Campisi Saveria, Missere Massimiliano, Midiri Massimo, Vallone Antonino, Renne Stefania, Schicchi Nicolò, Righi Riccardo, Mangione Maurizio, Positano Vincenzo, Pepe Alessia
Abstract excerpt
BACKGROUND: The causes and effects of genotypic heterogeneity in beta-thalassemia major (β-TM) have not been fully investigated. The aim of this multicentre study was to determine whether different genotype groups could predict the development of cardiovascular magnetic resonance abnormalities and cardiac complications. MATERIALS AND METHODS: We considered 708 β-TM patients (373 females, age 30.05±9.47 years)...
Topics
- Adult
- Cardiovascular Diseases
- Female
- Genetic Predisposition to Disease
- Humans
- Magnetic Resonance Imaging
- Male
- Prognosis
- Young Adult