Article
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.
BMC medical genetics - 30 Sept 2006
Thakur Nikita, Reddy D Nageshwar, Rao G Venkat, Mohankrishna P, Singh Lalji, Chandak Giriraj R
Abstract excerpt
BACKGROUND: Peutz-Jeghers syndrome (PJS) is a rare multi-organ cancer syndrome and understanding its genetic basis may help comprehend the molecular mechanism of familial cancer. A number of germ line mutations in the STK11 gene, encoding a serine threonine kinase have been reported in these patients. However, STK11 mutations do not explain all PJS cases. An earlier study reported absence of STK11 mutations in...
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