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Fumarase: From the TCA Cycle to DNA Damage Response and Tumor Suppression

25 Jul 2018

Abstract excerpt

Fumarase is an enzyme of the tricarboxylic acid (TCA) cycle in mitochondria, but in recent years, it has emerged as a participant in the response to DNA double strand breaks (DSBs) in the nucleus. In fact, this enzyme is dual-targeted and can be also readily detected in the mitochondrial and cytosolic/nuclear compartments of all the eukaryotic organisms examined. Intriguingly, this evolutionary conserved...

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PMID: 30090811
DOI: 10.3389/fmolb.2018.00068

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