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Human Fumarate Hydratase Is Dual Localized by an Alternative Transcription Initiation Mechanism

2 Apr 2016

Abstract excerpt

Fumarate hydratase (FH, fumarase), is a tricarboxylic acid cycle enzyme localized in the mitochondrial matrix. However, a common theme, conserved from yeast to human, is the existence of a large cytosolic population of FH. FH has been shown to function as a tumor suppressor gene and is now implicated in various diseases. We have previously indicated that the cytosolic echoform of FH has a role in the DNA damage...

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PMID: 27037871
DOI: 10.1111/tra.12397

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