Inference of fitness values and putative appearance time points for evolvable self-replicating molecules from time series of occurrence frequencies in an evolution reactor.

Abstract excerpt

We have established a translation-coupled RNA replication system within a cell-like compartment, and conducted an experimental evolution of the RNA molecules in the system. Then, we obtained a time series of occurrence frequencies of 91 individual genotypes through random sampling and next-generation sequencing. The time series showed a complex clonal interference and a polymorphic population called the...

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